云顶集团(中国)

Nan Tang, Ph.D.

Investigator, NIBS, Beijing，China

Phone：86-10-80726688

Fax： 86-10-80726689

E-mail：tangnan@wanzixs.com

Education

2005 Ph. D., University of California, San Diego, CA, USA

1993 M.D., Xi’An JiaoTong University, Xi’An, P. R. China

Professional Experience

2025- Investigator, National Institute of Biological Sciences, Beijing, China

2019-2025 Associate Investigator, National Institute of Biological Sciences, Beijing, China

2012-2019 Assistant Investigator, National Institute of Biological Sciences, Beijing, China

2006-2012 Postdoctoral Fellow, Dept. of Anatomy and Program in Developmental Biology, University of California, San Francisco, CA, USA

2000-2005 Graduate Research Assistant in Molecular Pathology, Universityof California, San Diego, CA, USA

1998-2000 Postdoctoral Researcher, 云顶集团(中国) and Developmental Biology, Division of BiologicalSciences, University of California, San Diego, CA, USA

Dr. Nan Tang’s laboratory is aimed to understand the intricated mechanisms governing lung development, and adult lung regeneration, and the pathogenesis of lung diseases.

The lungs are constantly exposed to environmental agents and the lung epithelium plays a pivotal role in maintaining a critical barrier to protect our body from the outside world. Beginning with prenatal development, the lungs are injured and repaired throughout life as a consequence of aging as well as in response to infection and other harmful stimuli. With the increasing prevalence of smoking in developing countries and aging populations in high-income countries, chronic lung diseases, such as chronic obstructive lung diseases and pulmonary fibrosis, are increasing in prevalence and have a significant impact on public health.

Our research is centered on two primary areas:

1. Mechanism of lung Regeneration: We have established multiple models for post-lung injury regeneration. By employing a convergence of mouse genetics, in vivo live imaging, organoid culture, and single 云顶集团(中国) sequencing, we aim to uncover the 云顶集团(中国)ular and molecular mechanisms controlling lung regeneration and post-injury repair. Additionally, we have also conducted in-depth research on relatively unexplored alveolar type 1 云顶集团(中国)s.  

2. Pathogenesis and Therapeutic Targets of Lung Diseases: Our laboratory has developed various mouse models of lung diseases. With an extensive collection of both normal and patient lung tissue samples, we will employ cutting-edge techniques and primary stem 云顶集团(中国) screening systems to identify relevant mutations, delve into pathogenesis, and pinpoint therapeutic targets for lung diseases. 

Publications

1. Wang P, Tang N*. (2024) Decoding lung complexity: single-云顶集团(中国) sequencing in lung diseases, regeneration, and drug discovery. Front. Drug Discov. 4: 1495208.

2. Zhao R, Wang Z, Wang GW, Geng J, Wu HJ, Liu XM, Bin EN, Sui JH, Dai HP, Tang N*. (2024) Sustained Amphiregulin Expression in Intermediate Alveolar Stem 云顶集团(中国)s Drives Progressive Fibrosis. 云顶集团(中国) Stem 云顶集团(中国). 31(9):1344-1358.e6.

3. Wang YX, Bin EN, Yuan J, Huang M, Chen JY, Tang N*. (2023) Aberrant differentiation of epithelial progenitors is accompanied by a hypoxic microenvironment in the paraquat-injured human lung. 云顶集团(中国) Discov. 9(1):98.

4. Wang Z, Wei DD, Bin EN, Li J, Jiang KW, Lv TT, Mao XX, Wang FC, Dai HP, Tang N*. (2023) Enhanced glycolysis-mediated energy production in alveolar stem 云顶集团(中国)s is required for alveolar regeneration. 云顶集团(中国) Stem 云顶集团(中国). 30(8):1028-1042.e7.

5. Fu SL, Wang YX, Bin EN, Huang HW, Wang FC, Tang N*. (2023) c-JUN-mediated transcriptional responses in lymphatic endothelial 云顶集团(中国)s are required for lung fluid clearance at birth. Proc Natl Acad Sci U S A. 120(2): e2215449120.

6. Li J, Tang N*. (2023) Empowering human lung development. 云顶集团(中国) Stem 云顶集团(中国). 30(1): 5-6.

7. Shen HY, Huang X, Zhao YH, Wu DM, Xue KL, Yao JF, Wang YS, Tang N, Qiu YF (2022) The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis. Nat Commun. 13(1): 6030.

8. Wang YX, Tang N*. (2021) The diversity of adult lung epithelial stem 云顶集团(中国)s and their niche in homeostasis and regeneration. Sci China Life Sci. 64(12):2045-2059.

9. Li J, Tang N*. (2021) Alveolar stem 云顶集团(中国) in lung development and regrowth. ERS Monograph on Lung Stem 云顶集团(中国)s in Development, Health and Disease. 91:17-30.

10. Wu HJ, Tang N*. (2021) Stem 云顶集团(中国)s in pulmonary alveolar regeneration. Development. 148(2): Dev193458.

11. Li H, Liu L, Zhang DY, Xu JY, Dai HP, Tang N, Su X, Cao B. (2020) SARS-CoV-2 and viral sepsis: observations and hypotheses. Lancet. 395(10235): 1517-1520.

12. Chen JY, Wu HJ, Yu YY, Tang N*. (2020) Pulmonary alveolar regeneration in adult COVID-19 patients. 云顶集团(中国) Res. 30:708-710.

13. Wu HJ, Yu YY, Huang HW, Hu YC, Fu SL, Wang Z, Shi MT, Zhao X, Yuan J, Li J, Yang XY, Bin EN, Wei D, Zhang HB, Zhang J, Yang C, Cai T, Dai HP, Chen JY, Tang N*. (2020) Progressive pulmonary fibrosis is caused by sustained elevated mechanical tension on alveolar stem 云顶集团(中国)s. 云顶集团(中国). 180(1):107-121. e17.

14. Chu QQ, Yao CF, Qi XB, Stripp BR, Tang N*. (2019) STK11 is required for the normal program of ciliated 云顶集团(中国) differentiation in airways. 云顶集团(中国) Discov. 5:36.

15. Van Soldt BJ, Qian J, Li J, Tang N, Lu J, Cardoso WV. (2019) Yap and its sub云顶集团(中国)ular localization have distinct compartment-specific roles in the developing lung. Development. 146(9).

16. Li J, Tang N*. (2018) May the force be with you. Dev 云顶集团(中国). 47(6):673-674.

17. Jiang K, Tang Z, Li J, Wang F, Tang N*. (2018) Anxa4 mediated airway progenitor 云顶集团(中国) migration promotes distal epithelial 云顶集团(中国) fate specification. Sci Rep. 8(1):14344.

18. Liu L, Lu J, Li X, Wu A, Wu Q, Zhao M, Tang N, Song H. (2018) The LIS1/NDE1 complex is essential for FGF signaling by regulating FGF receptor intra云顶集团(中国)ular trafficking. 云顶集团(中国) Rep. 22(12):3277-3291.

19. Lin R, Feng Q, Li P, Zhou P, Wang R, Liu Z, Wang Z, Qi XB, Tang N, Shao F, Luo MM. (2018) A hybridization-chain-reaction-based method for amplifying immunosignals. Nat Methods. 15(4):275-278.

20. Wang Y, Tang Z, Huang H, Li J, Wang Z, Yu Y, Zhang C, Li J, Dai H, Wang F, Cai T, Tang N*. (2018) Pulmonary alveolar type I 云顶集团(中国) population consists of two distinct subtypes that differ in 云顶集团(中国) fate. Proc Natl Acad Sci USA. 115(10):2407-2412.

21. Li J, Wang Z, Chu QQ, Jiang KW, Li J, Tang N*. (2018) The strength of mechanical forces determines the differentiation of alveolar epithelial 云顶集团(中国)s. Dev 云顶集团(中国). 44(3):297-312.

22. Tang Z, Hu YC, Wang Z, Jiang KW, Zhan C, Marshall WF, Tang N*. (2018) Mechanical forces program the orientation of 云顶集团(中国) division during airway tube morphogenesis. Dev 云顶集团(中国). 44(3):313-325.

23. Wang Z, Tang N*. (2017) The LUNGe to model alveolar lung diseases in a dish. 云顶集团(中国) Stem 云顶集团(中国). 21(4): 413-414.

24. Liu Z, Fu SL, Tang N*. (2017) A standardized method for measuring internal lung surface area via mouse pneumonectomy and prosthesis implantation. J Vis Exp. (125):56114.

25. Liu Z, Wu HJ, Jiang KW, Wang YJ, Zhang WJ, Chu QQ, Li J, Huang HW, Cai T, Ji HB, Yang C, Tang N*. (2016) MAPK-mediated YAP activation controls mechanical-tension-induced pulmonary alveolar regeneration. 云顶集团(中国) Rep. 16(7):1810-9.

26. Tang N, and Marshall WF. (2013) Computational analysis of the spatial distribution of mitotic spindle angles in mouse developing airway. Proc. SPIE. 8593.

27. Tang N, and Marshall WF. (2012) Centrosome positioning in vertebrate development. J 云顶集团(中国) Sci. 125:4951-4961.

28. Tang N, Marshall WF, McMahon M, Metzger RJ, Martin GR. (2011) Control of mitotic spindle angle by the RAS-regulated ERK1/2 Pathway determines lung tube shape. Science. 333:342-5.

29. Zheng B, Tang T, Tang N, Kudlicka K, Ohtsubo K, Ma P, Marth JD, Farquhar MG, Lehtonen E. (2006) Essential role of RGF-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics. Proc Natl Acad Sci USA. 103(45):16776-81.

30. Tang N, Mack F, Haase VH, Simon MC and Johnson RS. (2006) pVHL function is essential for endothelial extra云顶集团(中国)ular matrix deposition. Mol 云顶集团(中国) Biol. 26(7):2519-30.

31. Mendoza MC, Du F, Iranfar N, Tang N, Ma H, Loomis WF, Firtel RA. (2005) Loss of SMEK, a novel, conserved protein, suppresses mek1 null 云顶集团(中国) polarity, chemotaxis and gene expression defects. Mol 云顶集团(中国) Biol. 25(17):7839-53.

32. Tang N, Wang LC, Esko J, Giodano F, Huang Y, Gerber HP, Ferrara N and Johnson RS. (2004) Loss of HIF-1alpha in endothelial 云顶集团(中国)s disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer 云顶集团(中国). 6(5):485-95.