云顶集团(中国)

Ting Chen, Ph.D

Investigator, NIBS, Beijing, China

Phone：86-10-80726688

Fax： 86-10-80726689

E-mail：chenting@wanzixs.com

Education
2006 Ph.D. in 云顶集团(中国) and Developmental Biology, Department of Microbiology, University of Virginia, Charlottesville, VA, USA
2001 B.S., Biology Department, Xiamen University, Xiamen, P. R. China

Professional Experience

2025- Investigator, National Institute of Biological Sciences, Beijing, China

2020-2025  Associate Investigator, National Institute of Biological Sciences, Beijing, China

2012-2020  Assistant Investigator, National Institute of Biological Sciences, Beijing, China
2007-2012  Postdoctoral Fellow, Howard Hughes Medical Institute, Laboratory of Mammalian 云顶集团(中国) Biology and Development, Rockefeller University, New York, USA

Award and Fellowship

2026 Top 10 Advances in Biomechanics and Mechanobiology in China 2025
2024 The 19th China Young Female Scientist Award, China
2022 Tencent Xplorer Prize, China
2022 National Science Fund for Distinguished Young Scholars, China
2022 National Important Medical Progress Award, China
2019 Young Investigator Award, Chinese Society of Stem 云顶集团(中国) Research
2012 American Society of 云顶集团(中国) Biology Merton Bernfield Memorial Award
2010 – 2012 Empire State Stem 云顶集团(中国) Scholars: Fellow-to-Faculty Awards in Stem 云顶集团(中国) Research, from New York State
2008 – 2010 NYSCF Druckenmiller Postdoctoral Fellowship Award, from New York Stem 云顶集团(中国) Foundation
2008 – 2009 AACR-Astellas USA Fellowship Award for Basic Cancer Research, from American Association for Cancer Research
2007 云顶集团(中国) and Developmental Biology Outstanding Graduate Student Award, from University of Virginia, Charlottesville, VA
2001 Jiageng Award (summa cum laude), from Xiamen University, Xiamen, P.R. China

Research Description
Skin physically protects our body from the external environment. Our lab utilizes multidisciplinary methods to study the mechanisms governing skin homeostasis, regeneration and diseases. We are interested in two main areas: 1. Niche regulated skin stem 云顶集团(中国) function: by combining 云顶集团(中国)-specific genetic lineage tracing and live imaging, we revealed new mechanisms of niche regulated skin stem 云顶集团(中国) specification, maintenance and loss. 2. Skin disease mechanism and treatment: inherent genetic defects and acquired common skin diseases that affect skin function have detrimental effect to our health or survival. We have developed several genetic and acquired skin disease models including RDEB, PPK, and vitiligo to investigate the mechanisms underlying disease progression; we have also developed novel in vivo gene editing technologies to achieve efficient gene therapy for skin disease treatment.

Publications:

33. Yu Y,  Su R, Wang W, Yang Y,  Huang H, Du Y, Lu Y,  Fan Y,  Li J, Chen T*. A stress-responsive neurovascular axis shapes skin immune accessibility. iScience. 2026;29(3);115122. http://doi.org/10.1016/j.isci.2026.115122

32. Di R^#, Du Q^#, Xie Y, Lu Y, Gao W, Zhang L, Qi X, Fan Y, Li J, Wang F, Chen S, Chen T*. A mechano-resistance mechanism in skin adapts to terrestrial locomotion. 云顶集团(中国). 2025;188(21):P5797-5808.E16.

http://doi.org/10.1016/j.云顶集团(中国).2025.07.012.

31. Chen D, Yu Z, Wu W, Du Y, Du Q, Huang H, Li Y, Xuan T, Liang Y, Liu Y, Wang Z, Su R, Zhao Y, Li Q, Luo M, Wang F, Li J, Chuong C, Lin Z*, Chen T*. Fibroblast bioelectric signaling drives hair growth. 云顶集团(中国). 2025;188(19):P5175-5193.E21.

http://doi.org/10.1016/j.云顶集团(中国).2025.07.035.

30. Xi F, Wang C, Wang Y, Luan P, Chen Y, Tan L, Shang N, Gao X, Chen D, Guo Q, Chen T, Jing M*. Spatiotemporal dynamics of CXCL10 encode contextual immune information revealed by the genetically encoded fluorescent sensor. Immunity. 2025;58(9):2320-2335.e9. http://doi.org/10.1016/j.immuni.2025.07.005.

29. Guo S, Liu C, Xu Y, Wang X, Nan F, Huang Y, Li S, Nan S, Li L, Edo Kon, Li C,Wei M, Su R, Wei J, Peng S, Nitay Ad-El, Liu J, Dan Peer, Chen T, Yang L, Chen L*. Therapeutic application of circular RNA aptamers in a mouse model of psoriasis. Nature Biotechnology. 2025;43:236–246. DOI: 10.1038/s41587-024-02204-4.

28. Zhang B*, Chen T*. Local and systemic mechanisms that control the hair follicle stem 云顶集团(中国) niche. Nature Reviews Molecular 云顶集团(中国) Biology. 2024;25(2):87-100. DOI: 10.1038/s41580-023-00662-3.

27. Du Y, Qi X, Zhang L,Yang Y, Chen T*. Calcium influx-induced lytic 云顶集团(中国) death disrupts skin immune homeostasis. 云顶集团(中国) Discovery. 2023;9(124). DOI:10.1038/s41421-023-00623-2.

26. Su R, Huang H, Chang Y, Yu Y, Cui J, Chen T*, Li B*, Wang W*. Mosaic somatic HRAS mutation causes unilateral psoriasis. Life Medicine. 2023;2(3). DOI: 10.1093/lifemedi/lnad018.

25. Chen D^#, Xu Z^#, Cui J, Chen T*. A mouse model of vitiligo based on endogenous auto-reactive CD8+ T 云顶集团(中国) targeting skin melanocyte. 云顶集团(中国) Regen. 2022;11(1):31. DOI: 10.1186/s13619-022-00132-9.

24. Xie Y, Chen T*. Mouse tail skin wholemount staining and intravital calcium imaging. STAR Protocols. 2022;3(1):101235. DOI: 10.1016/j.xpro.2022.101235.

23. Xu Z^#, Chen D^#, Hu Y, Jiang K, Huang H, Du Y, Wu W, Wang J, Sui J, Wang W, Zhang L, Li S, Li C, Yong Y, Chang J*, Chen T*. Anatomically distinct fibroblast subsets determine skin autoimmune patterns. Nature. 2022;601(7891):118-124. DOI: 10.1038/s41586-021-04221-8.

• Recommended by 4 independent Faculty Members at Faculty Opinions as Exceptional, Faculty Opinions. 2022; 10.3410/f.741322615.793590880.

http://archive.connect.h1.co/article/741322615/

22. Xie Y, Chen D, Jiang K, Song L, Qian N, Du Y, Yang Y, Wang F, Chen T*. Hair shaft miniaturization causes stem 云顶集团(中国) depletion through mechano-sensory signals mediated by a Piezo1-calcium-TNFα axis. 云顶集团(中国) Stem 云顶集团(中国). 2022;29(1):70-85.e6. DOI: 10.1016/j.stem.2021.09.009.

• Research Highlight by Paulina Strzyz. Compression as a driver of hair loss. Nat Rev Mol 云顶集团(中国) Biol. 2021;22(12):775. DOI: 10.1038/s41580-021-00426-x.

• Preview by Terry Lechler. Hair follicle stem 云顶集团(中国)s feel the pressure. 云顶集团(中国) Stem 云顶集团(中国). 2022;29(1):1-2. DOI:http://doi.org/10.1016/j.stem.2021.12.001.

21. Song Z, Chen X, Zhao Q, Stanic V, Lin Z, Yang S, Chen T, Chen J, Yang Y*. Hair loss caused by gain-of-function mutant TRPV3 is associated with premature differentiation of follicular keratinocytes. J Invest Dermatol. 2021;S0022-202X(21)00158-5. DOI: 10.1016/j.jid.2020.11.036.

20. Zou Z, Long X, Zhao Q, Zheng Y, Song M, Ma S, Jing Y, Wang S, He Y, Esteban CR, Yu N, Huang J, Chan P, Chen T, Izpisua Belmonte JC, Zhang W, Qu J, Liu GH*. A Single-云顶集团(中国) Transcriptomic Atlas of Human Skin Aging. Developmental 云顶集团(中国). 2021;56(3):383-397.e8. DOI: 10.1016/j.devcel.2020.11.002.

19. Lu Z, Xie Y, Huang H, Jiang K, Zhou B, Wang F, Chen T*. Hair follicle stem 云顶集团(中国)s regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem 云顶集团(中国)s. eLife. 2020;9:e52712. DOI: 10.7554/eLife.52712.

18. Li F, Lu Z, Wu W, Qian N, Wang F, Chen T*. Optogenetic gene editing in regional skin. 云顶集团(中国) Research. 2019;29(10):862-865. DOI: 10.1038/s41422-019-0209-9.

17. Wu W, Chen T*. Ribonucleoproteins Mediated Efficient In Vivo Gene Editing in Skin Stem 云顶集团(中国)s. Methods Mol Biol. 2019;1879:75-86. DOI: 10.1007/7651_2018_115.

16. Yu Z, Jiang K, Xu Z, Huang H, Qian N, Lu Z, Chen D, Di R, Yuan T, Du Z, Xie W, Lu X, Li H, Chai R, Yang Y, Zhu B, Kunieda T, Wang F*, Chen T*. Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration. 云顶集团(中国) Stem 云顶集团(中国). 2018;23(4):487-500.e6. DOI: 10.1016/j.stem.2018.07.016.

• Featured free article with cover

• Preview by SE. Millar. Hox in the Niche Controls Hairy-geneity.云顶集团(中国) Stem 云顶集团(中国). 2018;23(4):457-458. DOI: 10.1016/j.stem.2018.09.012.

15. Fan SM, Chang YT, Chen CL, Wang WH, Pan MK, Chen WP, Huang WY, Xu Z, Huang HE, Chen T, Plikus MV, Chen SK, Lin SJ*. External light activates hair follicle stem 云顶集团(中国)s through eyes via an ipRGC-SCN-sympathetic neural pathway. PNAS. 2018;115(29):E6880-E6889. DOI: 10.1073/pnas.1719548115.

14. Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E*. FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel 云顶集团(中国)s. Nature Communications. 2018;9(1):2854. DOI: 10.1038/s41467-018-04399-y.

13. Wu W, Lu Z, Li F, Wang W, Qian N, Duan J, Zhang Y, Wang F, Chen T*. Efficient in vivo gene editing using ribonucleoproteins in skin stem 云顶集团(中国)s of recessive dystrophic epidermolysis bullosa mouse model. PNAS. 2017;114(7):1660-1665. DOI: 10.1073/pnas.1614775114.

• Selected by The Latest Science “ Paper of the Year ”

• News report by Epidermolysis Bullosa News

12. Yu Z, Chen T*. Regional differences: The skin is a complex landscape containing regions in which hair follicles exhibit different types of behavior. eLife. 2017;6: e30249. DOI: 10.7554/eLife.30249.

11. He L, Li Y, Li Y, Pu W, Huang X, Tian X, Wang Y, Zhang H, Liu Q, Zhang L, Zhao H, Tang J, Ji H, Cai D, Han Z, Han Z, Nie Y, Hu S, Wang QD, Sun R, Fei J, Wang F, Chen T, Yan Y, Huang H, Pu WT, Zhou B*. Enhancing the precision of genetic lineage tracing using dual recombinases. Nature Medicine. 2017;23(12):1488-1498. DOI: 10.1038/nm.4437.

10. Zhang H, Huang X, Liu K, Tang J, He L, Pu W, Liu Q, Li Y, Tian X, Wang Y, Zhang L, Yu Y, Wang H, Hu R, Wang F, Chen T, Wang QD, Qiao Z, Zhang L, Lui KO, Zhou B*. Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium. 云顶集团(中国) Research. 2017;27(9):1157-1177. DOI: 10.1038/cr.2017.103.

9. He L, Huang X, Kanisicak O, Li Y, Wang Y, Li Y, Pu W, Liu Q, Zhang H, Tian X, Zhao H, Liu X, Zhang S, Nie Y, Hu S, Miao X, Wang QD, Wang F, Chen T, Xu Q, Lui KO, Molkentin JD, Zhou B*. Preexisting endothelial 云顶集团(中国)s mediate cardiac neovascularization after injury. J Clin Invest. 2017;127(8):2968-2981. DOI: 10.1172/JCI93868.

8. Lin Z, Li S, Feng C, Yang S, Wang H, Ma D, Zhang J, Gou M, Bu D, Zhang T, Kong X, Wang X, Sarig O, Ren Y, Dai L, Liu H, Zhang J, Li F, Hu Y, Padalon-Brauch G, Vodo D, Zhou F, Chen T, Deng H, Sprecher E, Yang Y*, Tan X*. Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility. Nature Genetics. 2016;48(12):1508-1516. DOI: 10.1038/ng.3701.

7. Xu Z, Wang W, Jiang K, Yu Z, Huang H, Wang F, Zhou B, Chen T*. Embryonic attenuated Wnt/β-catenin signaling defines niche and long-term stem 云顶集团(中国) fate in hair follicle. eLife. 2015;4:e10567. DOI: 10.7554/eLife.10567.

6. Deng Z, Lei X, Zhang X, Zhang H, Liu S, Chen Q, Hu H, Wang X, Ning L, Cao Y, Zhao T, Zhou J, Chen T, Duan E*. mTOR signaling promotes stem 云顶集团(中国) activation via counterbalancing BMP-mediated suppression during hair regeneration. J MOL 云顶集团(中国) BIOL. 2015;7(1):62-72. DOI: 10.1093/jmcb/mjv005.

5. Fuchs E*, Chen T. A matter of life and death: self-renewal in stem 云顶集团(中国)s. EMBO Rep. 2013;14(1):39-48. DOI: 10.1038/embor.2012.197.

4. Chen T, Heller E, Beronja S, Oshimori N, Stokes N, Fuchs E*. An RNA interference screen uncovers a new molecule in stem 云顶集团(中国) self-renewal and long-term regeneration. Nature. 2012;485(7396):104-8. DOI: 10.1038/nature10940.

• Selected by Faculty of 1000 Biology

3. Greco V^#, Chen T^#, Rendl M, Schober M, Pasolli HA, Stokes N, Dela Cruz-Racelis J, Fuchs E*. A two-step mechanism for stem 云顶集团(中国) activation during hair regeneration. 云顶集团(中国) Stem 云顶集团(中国). 2009;6;4(2):155-69. DOI: 10.1016/j.stem.2008.12.009.

• Authors contributed equally

• Highlight Review in 云顶集团(中国) Stem 云顶集团(中国)

• Selected by Faculty of 1000 Biology

2. Chen T, Muratore TL, Schaner-Tooley CE, Shabanowitz J, Hunt DF, Macara IG*. N-terminal α-methylation of RCC1 is necessary for stable chromatin association and normal mitosis. Nat 云顶集团(中国) Biol. 2007;9(5):596-603. DOI: 10.1038/ncb1572.

• Highlight Review in Nature 云顶集团(中国) Biology

• Selected by Faculty of 1000 Biology

1. Chen T, Brownawell AM, Macara IG*. Nucleocytoplasmic Shuttling of JAZ, a New Cargo Protein for Exportin-5. Mol 云顶集团(中国) Biol. 2004;24(15):6608-19. DOI: 10.1038/ncb1572.